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[Hypophyseal-adrenal system function in disseminated breast cancer]
Voprosy Onkologii
|January 1, 1982
Summary
Pituitary-adrenal system function is altered in patients with advanced breast cancer, showing decreased 17-oxogenic steroids excretion and elevated blood cortisol. This suggests relative pituitary-adrenal insufficiency, potentially benefiting from adaptogens and supportive therapies.
Area of Science:
- Endocrinology
- Oncology
- Biochemistry
Background:
- Disseminated breast cancer can impact endocrine function.
- The pituitary-adrenal axis plays a crucial role in stress response and metabolism.
Purpose of the Study:
- To investigate the functional state of the pituitary-adrenal system in patients with disseminated breast cancer.
- To identify potential endocrine dysfunctions associated with advanced breast cancer.
Main Methods:
- Studied 94 patients diagnosed with disseminated breast cancer.
- Assessed pituitary-adrenal system function through urinary 17-oxogenic steroids (17-OCS) excretion and blood cortisol levels.
Main Results:
- Observed a significant decrease in urinary 17-OCS excretion.
- Detected an elevated level of cortisol in the blood.
- Interpreted these findings as indicative of relative (extra-adrenal) pituitary-adrenal failure.
Conclusions:
- Patients with disseminated breast cancer exhibit impaired pituitary-adrenal function.
- Recommends long-term therapeutic measures including adaptogens, vitamins, and hepatotropic preparations to support endocrine balance.