[Genealogic analysis of peptic ulcer of the duodenum]

The results are presented from a meticulous genealogical study, to III stage of family descent, of 348 patients with duodenal ulcer and 101 healthy subjects. The index of hereditary defects, with the strictly collected data, revealed that in 3/4 of the patients degree greater than families some other representatives with ulcer disease were found. With broadening the circle and including more relatives, that index regularly grows. The incidence of ulcer diseases among the relatives of the propositus with duodenal ulcer is 5 to 10 times more frequent as compared with the corresponding stages of kinship among the healthy controls. The duodenal ulcer, in the hereditary defective patients, is manifested with an average of 8--10 years earlier. The same localization of the ulcer niche was found in 91.12 per cent among the blood relatives of the propositi. The males suffer 2.5 times more often from duodenal ulcer.