[Complex study of glycoproteins in liver disease]

The glycoproteins (GP) of 329 patients with liver diseases and 60 clinically healthy subjects were complexly studied: sialic acid, orozomucoid, haptoglobin, ceruloplasmin, cholinesterase, hexosamine and fucose. Modern laparoscopic, bioscopic, histochemical and histomorphological methods were used in making the diagnosis and determination of the disease phase; The liver diseases are characterized by quantitative and qualitative differences in the character of the GP changes in serum. GP are mostly changed in acute viral hepatitis, cirrhosis, extrahepatic cholestasis and liver tumours, less in chronic aggressive hepatitis and no change in chronic persistent hepatitis and steatosis. The complex GP study is of significance in the characteristic of the activity of the pathological process, in the specification of the liver function as well as for the prognosis of a certain disease.