Related Experiment Video

Updated: Jul 27, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

[Changes in serum lipoproteins in patients with ischemic heart disease at an early age]

E Malamov, A Kiriakov, I Tsenov

    Vutreshni Bolesti
    |January 1, 1982
    PubMed

    Insights

    Hyperlipidemia (HLP) and dyslipoproteinemia (DLP) are prevalent in ischemic heart disease (IHD) patients, characterized by altered lipoprotein profiles. These lipid abnormalities correlate with IHD progression, highlighting their clinical significance.

    Area of Science:

    • Cardiovascular Medicine
    • Clinical Biochemistry
    • Lipid Metabolism

    Context:

    • Chronic ischemic heart disease (IHD) affects a significant population, with lipid profiles playing a crucial role in its pathogenesis.
    • Understanding lipoprotein abnormalities in IHD is essential for risk stratification and management.

    Purpose:

    • To investigate the prevalence and characteristics of hyperlipidemia (HLP) and dyslipoproteinemia (DLP) in patients with chronic IHD.
    • To analyze the association between specific lipoprotein profiles and the severity of IHD.

    Summary:

    • Serum lipoprotein profiles were analyzed in 37 IHD patients and 100 healthy controls. HLP/DLP were found in 86.5% of IHD patients, with Type IV, IIB, and IIa being most common.
    • Key findings include decreased HDLP-Chol and increased HDLP-Tg, leading to a reduced intralipoprotein index (1(2)).
    • Lipoprotein index II (LDLP-Chol and VLDLP-Chol/HDLP-Chol) was significantly elevated in all IHD groups, including those with normolipoproteinemia (NLP).

    Impact:

    • The study reveals a strong correlation between specific HLP types and IHD severity, with Type IV HLP and DLP decreasing as IHD progresses, while Types IIa and IIb increase.
    • Elevated lipoprotein index II serves as a significant indicator across all IHD stages, even with normal overall lipid levels.
    • These findings underscore the importance of comprehensive lipoprotein profiling in managing IHD and suggest potential biomarkers for disease progression.

    More Related Videos

    Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles09:15

    Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

    Published on: November 10, 2017

    Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation06:47

    Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

    Published on: January 28, 2021

    Related Concept Videos

    Inflammation01:38

    Inflammation

    Overview
    Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

    Lipid-Lowering Drugs: Statins and Miscellaneous Agents

    Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
    Lipids: Dietary Sources and Requirements01:18

    Lipids: Dietary Sources and Requirements

    Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
    Cholesterol: Significance and Regulation01:29

    Cholesterol: Significance and Regulation

    Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
    Considering cholesterol and...
    Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

    Blood Studies for Cardiovascular System III: Serum Lipid Profile

    Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
    Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
    Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
    Atherosclerosis III: Management01:26

    Atherosclerosis III: Management

    Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...