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[Pituitary gland extract insufflation lung]

G Liebetrau, W Pielesch, U Tuschy

Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete

|April 1, 1982

Summary

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Allergic alveolitis and pulmonary fibrosis can develop in patients with diabetes insipidus due to posterior pituitary extract snuffing. Switching to synthetic preparations can prevent this adverse effect.

Area of Science:

Pulmonary Medicine
Endocrinology
Allergology

Background:

Diabetes insipidus is a condition characterized by excessive thirst and urination.
Posterior pituitary extracts have been used in treating diabetes insipidus.
Allergic alveolitis is an inflammatory lung condition triggered by inhaled allergens.

Observation:

Two patients with diabetes insipidus developed allergic alveolitis.
The condition progressed to pulmonary fibrosis in these patients.
The alveolitis was linked to the use of intranasal posterior pituitary extracts.

Findings:

The pathomechanism mirrors other hypersensitivity pneumonitis, such as farmer's lung.
The adverse pulmonary effects are associated with protein-containing pituitary extracts.

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Irreversible lung damage leads to poor prognosis.

Implications:

Therapy for diabetes insipidus should transition to synthetic preparations to avoid protein-induced allergic alveolitis.
Early diagnosis and cessation of exposure are crucial.
Limited therapeutic options exist for established pulmonary fibrosis, emphasizing preventative strategies.