Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systolic time intervals in the evaluation of thyroid dysfunction

E Lien, S Aanderud

    Acta Medica Scandinavica
    |January 1, 1982
    PubMed
    Summary

    Thyroid dysfunction significantly impacts heart function. Thyrotoxicosis increases myocardial contractility, while hypothyroidism reduces it, as shown by changes in systolic time intervals.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis.

    Frontiers in immunology·2022
    Same author

    ADCK3 mutations with epilepsy, stroke-like episodes and ataxia: a POLG mimic?

    European journal of neurology·2016
    Same author

    Cytokine bioassays.

    Methods in molecular medicine·2011
    Same author

    Variations in concentrations of lactoferrin in human milk: a nine country survey.

    Advances in experimental medicine and biology·2004
    Same author

    Stimulation of toll-like receptor 2 in mononuclear cells from HIV-infected patients induces chemokine responses: possible pathogenic consequences.

    Clinical and experimental immunology·2004
    Same author

    Cytomegalovirus infection induces production of human interleukin-10 in macrophages.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2003

    Area of Science:

    • Cardiology
    • Endocrinology
    • Physiology

    Background:

    • Thyroid hormones play a crucial role in cardiovascular function.
    • Alterations in thyroid status, such as thyrotoxicosis and hypothyroidism, are known to affect cardiac performance.
    • Systolic time intervals provide non-invasive insights into myocardial contractility and cardiac function.

    Purpose of the Study:

    • To investigate the impact of thyrotoxicosis and hypothyroidism on systolic time intervals.
    • To assess changes in pre-ejection period (PEP) and left ventricular ejection time (LVET) in patients with thyroid dysfunction.
    • To evaluate the reversibility of these changes after achieving a euthyroid state.

    Main Methods:

    • Studied ten thyrotoxic and ten hypothyroid patients.
    • Measured systolic time intervals, including PEP and LVET, corrected for heart rate (PECc and LVETc).
    • Re-evaluated intervals after therapeutic normalization of thyroid function.

    Main Results:

    • PECc and PEP/LVET ratios were significantly decreased in thyrotoxic patients (p<0.01) and increased in hypothyroid patients (p<0.001) compared to euthyroid values.
    • LVETc intervals were significantly prolonged in both groups (p<0.001).
    • Four hypothyroid patients showed markedly increased PEP/LVET ratios (>0.60).

    Conclusions:

    • Thyrotoxicosis is associated with increased myocardial contractility, independent of adrenergic blockade.
    • Hypothyroidism is linked to reduced myocardial contractility.
    • Systolic time intervals are sensitive indicators of thyroid-related cardiac dysfunction.

    Related Experiment Videos