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Related Experiment Videos

Disulfiram acceptors and refusers: do they differ?

P M O'Neil, J C Roitzsch, J P Giacinto

    Addictive Behaviors
    |January 1, 1982
    PubMed
    Summary
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    This study found no significant personality or mood differences between alcoholics who accepted or refused disulfiram (Antabuse). Agreement to take disulfiram does not indicate greater motivation for abstinence.

    Area of Science:

    • Psychiatry
    • Psychology
    • Addiction Medicine

    Background:

    • Disulfiram (Antabuse) is a medication used in alcohol dependence treatment.
    • Patient acceptance of disulfiram may be influenced by various factors.
    • Understanding these factors can optimize treatment adherence.

    Purpose of the Study:

    • To investigate personality and mood state correlates of disulfiram acceptance in alcoholics.
    • To determine if accepting disulfiram reflects increased motivation for abstinence.

    Main Methods:

    • 104 male veterans in inpatient alcohol treatment were assessed.
    • Participants completed the Minnesota Multiphasic Personality Inventory (MMPI), Profile of Mood States (POMS), and State-Trait Anxiety Inventory (STAI).
    • Subjects were categorized as disulfiram acceptors or refusers.

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    Main Results:

    • No significant differences were found in age, race, personality, or mood states between acceptors and refusers.
    • A trend suggested acceptors scored higher on the MMPI masculinity-femininity scale (p < .06).
    • MMPI profile code types did not differ between groups.

    Conclusions:

    • Acceptance of disulfiram treatment in this cohort was not associated with distinct personality or mood profiles.
    • The findings do not support the assumption that accepting disulfiram indicates higher motivation for sobriety.
    • Contextual factors may play a more significant role in treatment decisions.