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Reversible hypertrophic osteoarthropathy associated with cyanotic congenital heart disease
American Journal of Diseases of Children (1960)
|August 1, 1982
Insights
Congenital cyanotic heart disease (CCHD) can lead to hypertrophic osteoarthropathy (HOA). Surgical correction of CCHD resolved HOA symptoms in two patients, suggesting a direct link between these conditions.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Rheumatology
Background:
- Congenital cyanotic heart disease (CCHD) is a group of heart defects present at birth causing insufficient oxygen in the blood.
- Hypertrophic osteoarthropathy (HOA) is a rare condition characterized by bone and joint abnormalities, often secondary to other diseases.
Observation:
- Two patients with CCHD developed severe, long-standing cyanosis and hypoxia.
- These patients subsequently manifested clinical and radiographic signs of hypertrophic osteoarthropathy (HOA).
Findings:
- Surgical intervention, either corrective or palliative, led to the complete resolution of bone and joint lesions in both patients.
- The resolution of HOA symptoms post-cardiac surgery strongly suggests an etiological connection.
Implications:
- This case series highlights a potential link between CCHD and the development of HOA.
- Understanding this association may improve diagnostic and therapeutic approaches for patients with CCHD and related complications.
- Further research is warranted to elucidate the precise mechanisms underlying HOA in the context of CCHD.
Abstract:
We treated two patients with congenital cyanotic heart disease (CCDH) in whom associated hypertrophic osteoarthropathy (HOA) developed. Both were severely cyanotic and hypoxic for many years before HOA was fully manifested. Clinical and roentgenographic indications of bone and joint lesions disappeared completely shortly after corrective of palliative surgery. There appears to be an etiologic connection between HOA and CCHD.