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Implantation of Total Artificial Heart in Congenital Heart Disease
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Reversible hypertrophic osteoarthropathy associated with cyanotic congenital heart disease

M Frand, G Koren, Z Rubinstein

    American Journal of Diseases of Children (1960)
    |August 1, 1982
    PubMed

    Insights

    Congenital cyanotic heart disease (CCHD) can lead to hypertrophic osteoarthropathy (HOA). Surgical correction of CCHD resolved HOA symptoms in two patients, suggesting a direct link between these conditions.

    Area of Science:

    • Cardiology
    • Pediatric Cardiology
    • Rheumatology

    Background:

    • Congenital cyanotic heart disease (CCHD) is a group of heart defects present at birth causing insufficient oxygen in the blood.
    • Hypertrophic osteoarthropathy (HOA) is a rare condition characterized by bone and joint abnormalities, often secondary to other diseases.

    Observation:

    • Two patients with CCHD developed severe, long-standing cyanosis and hypoxia.
    • These patients subsequently manifested clinical and radiographic signs of hypertrophic osteoarthropathy (HOA).

    Findings:

    • Surgical intervention, either corrective or palliative, led to the complete resolution of bone and joint lesions in both patients.
    • The resolution of HOA symptoms post-cardiac surgery strongly suggests an etiological connection.

    Implications:

    • This case series highlights a potential link between CCHD and the development of HOA.
    • Understanding this association may improve diagnostic and therapeutic approaches for patients with CCHD and related complications.
    • Further research is warranted to elucidate the precise mechanisms underlying HOA in the context of CCHD.

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