Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Impaired pulmonary function as a risk factor for mortality

T H Beaty, B H Cohen, C A Newill

    American Journal of Epidemiology
    |July 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Research challenges in central nervous system manifestations of inborn errors of metabolism.

    Molecular genetics and metabolism·2010
    Same author

    Treatment strategies for medulloblastoma and primitive neuroectodermal tumors.

    Neurosurgical focus·2006
    Same author

    Phase I study of thalidomide for the treatment of plexiform neurofibroma in neurofibromatosis 1.

    Neurology·2003
    Same author

    Clinical, genetic and histopathologic findings in two siblings with muscle-eye-brain disease.

    European journal of ophthalmology·2002
    Same author

    Treatment of mitochondrial cytopathies.

    Seminars in neurology·2001
    Same author

    Diagnostic yield muscle biopsy in patients with clinical evidence of mitochondrial cytopathy.

    American journal of clinical pathology·2001

    Pulmonary function impairment significantly increases short-term mortality risk, even after accounting for age, sex, and smoking. This finding highlights impaired lung function as a critical predictor of survival across diverse populations.

    Area of Science:

    • Pulmonary Medicine
    • Epidemiology
    • Public Health

    Background:

    • Pulmonary function impairment is a common condition with potential systemic health implications.
    • Previous studies suggest a link between reduced lung function and increased mortality, but comprehensive data adjusting for multiple risk factors is needed.

    Purpose of the Study:

    • To investigate the association between pulmonary function impairment and short-term mortality.
    • To determine if pulmonary function impairment remains a significant risk factor for mortality after adjusting for age, sex, and smoking.

    Main Methods:

    • Prospective follow-up study of 2539 individuals from 1976 to 1981.
    • Utilized survival analysis with the proportional hazards model.
    • Defined pulmonary function impairment as forced expiratory volume in one second less than 68% of forced vital capacity.

    Related Experiment Videos

    Main Results:

    • Pulmonary function impairment was identified as a significant risk factor for short-term mortality.
    • Predicted risk curves for impaired individuals were consistently higher across all race-sex categories and ages.
    • Survival analysis revealed a steeper decline in estimated survival for individuals with poor pulmonary function, even after adjusting for age, race, and smoking.

    Conclusions:

    • Impaired pulmonary function is an independent risk factor for short-term mortality.
    • This impairment may contribute to pathogenic mechanisms underlying both respiratory and nonrespiratory diseases.
    • Pulmonary function status is a crucial indicator for assessing mortality risk.