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Related Experiment Videos

Acyclovir in severe herpes virus infections

J W van der Meer, J Versteeg

    The American Journal of Medicine
    |July 20, 1982
    PubMed
    Summary

    Intravenous acyclovir effectively treated severe herpes virus infections in 45 patients. The antiviral medication showed significant benefits, particularly for herpes simplex virus, with minimal toxicity observed.

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    Area of Science:

    • Virology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Severe herpes virus infections pose significant health risks, especially in immunocompromised individuals.
    • Acyclovir is a known antiviral agent used for herpes virus management.
    • Limited data may exist on intravenous acyclovir's efficacy across various severe herpes infections.

    Purpose of the Study:

    • To evaluate the efficacy and safety of intravenous acyclovir in patients with severe herpes virus infections.
    • To assess the drug's effectiveness in different types of herpes infections, including varicella, herpes zoster, and herpes simplex.
    • To identify patient subgroups that may benefit most from acyclovir treatment.

    Main Methods:

    • A cohort of 45 patients with severe herpes virus infections received intravenous acyclovir for five days.
    • Patients were categorized by the type of herpes virus infection: varicella, herpes zoster, or herpes simplex.
    • Data on treatment outcomes, including beneficial effects and adverse events, were collected and analyzed.

    Main Results:

    • No patient mortality was attributed to the viral infections.
    • Acyclovir demonstrated clear benefits in 8 patients (6 with herpes simplex) and probable benefits in 21 patients.
    • Treatment effects were doubtful or absent in 16 patients, with no impact on established neurologic damage. Transient transaminase elevation and infusion thrombophlebitis were the only noted toxicities.

    Conclusions:

    • Intravenous acyclovir is a safe and potentially effective treatment for severe herpes virus infections, particularly herpes simplex.
    • The study highlights the drug's efficacy in a significant portion of patients, with a favorable safety profile.
    • Further research may be warranted to optimize acyclovir use in specific herpes virus infection contexts.

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