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Related Experiment Videos

Persistent strongyloidiasis in an immunodeficient patient

J H Shelhamer, F A Neva, D R Finn

    The American Journal of Tropical Medicine and Hygiene
    |July 1, 1982
    PubMed
    Summary
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    A common variable immunodeficiency patient with persistent Strongyloides stercoralis infection showed poor treatment response. Long-term, interrupted thiabendazole therapy ultimately led to cure.

    Area of Science:

    • Immunology
    • Infectious Diseases
    • Gastroenterology

    Background:

    • Common variable immunodeficiency (CVI) is a primary immunodeficiency characterized by impaired antibody production.
    • Strongyloides stercoralis is an opportunistic helminthic pathogen that can cause chronic or hyperinfection in immunocompromised individuals.

    Observation:

    • A 56-year-old female with acquired CVI presented with persistent gastrointestinal and pulmonary Strongyloides stercoralis infection.
    • Despite repeated thiabendazole treatments, Strongyloides larvae recurred upon cessation, with minimal symptoms and normal small bowel histology.
    • The patient's immunodeficiency was hypothesized to contribute to the lack of symptomatology and poor treatment response.

    Findings:

    • Persistent Strongyloides stercoralis infection in an immunocompromised host.

    Related Experiment Videos

  • Recalcitrant infection despite standard thiabendazole therapy.
  • Successful eradication of Strongyloides stercoralis following a modified, low-dose, long-term interrupted thiabendazole treatment regimen.

    • Implications:

    • Highlights the challenges in treating opportunistic infections in patients with primary immunodeficiencies.
    • Suggests that modified treatment protocols may be necessary for managing Strongyloides stercoralis in immunocompromised individuals.
    • Underscores the importance of considering underlying immunodeficiency when evaluating treatment efficacy for parasitic infections.