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Pulmonary changes in schistosomal cor pulmonale

M Sadigursky, Z A Andrade

    The American Journal of Tropical Medicine and Hygiene
    |July 1, 1982
    PubMed
    Summary
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    Schistosomal cor pulmonale causes lung vascular changes. Early fibrin deposition and cell hyperplasia lead to complex plexiform lesions in small arteries, impacting pulmonary blood flow.

    Area of Science:

    • Pathology
    • Cardiovascular Science
    • Parasitology

    Background:

    • Schistosomal cor pulmonale is a severe complication of schistosomiasis.
    • Pulmonary vascular remodeling is a key feature of this condition.
    • Understanding the early vascular changes is crucial for potential interventions.

    Purpose of the Study:

    • To investigate the early histopathological changes in the pulmonary vasculature of schistosomal cor pulmonale.
    • To characterize the formation and structure of plexiform lesions in affected lungs.
    • To elucidate the arterial origin and morphology of these vascular abnormalities.

    Main Methods:

    • Necropsy was performed on 32 cases of schistosomal cor pulmonale.
    • Conventional histological techniques and serial sectioning were employed for lung tissue analysis.

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  • Plastic vascular casting was utilized to visualize the pulmonary arterial system.

    • Main Results:

    • Early changes included fibrin deposition and endothelial cell hyperplasia in small arteries and arterioles.
    • Complex fibrin thrombus organization, revascularization, and vessel dilatation led to plexiform lesions.
    • Vascular casts revealed glomeruloid, purely arterial lesions originating from small arteries.

    Conclusions:

    • Schistosome eggs trigger significant early vascular changes in the pulmonary arteries.
    • The development of plexiform lesions involves thrombus organization and neovascularization.
    • These arterial lesions are a distinct feature of schistosomal pulmonary vascular disease.