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[Suicide with beta-methyldigoxin (author's transl)]

N Rietbrock, H Wojahn, J Weinmann

Deutsche Medizinische Wochenschrift (1946)

|November 17, 1978

Summary

This summary is machine-generated.

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A woman died from a beta-methyldigoxin overdose within an hour. Postmortem analysis revealed significant glycoside levels in plasma and heart tissue, indicating early distribution stage toxicity.

Area of Science:

Pharmacology
Toxicology
Forensic Science

Background:

Beta-methyldigoxin is a cardiac glycoside used to treat heart conditions.
Overdose can lead to severe toxicity and potentially death.

Observation:

A 50-year-old female ingested a lethal dose of beta-methyldigoxin.
Death occurred approximately 60 minutes after ingestion.
Postmortem samples were collected 163 hours after death.

Findings:

Radioimmunoassay detected beta-methyldigoxin in plasma (75.1 ng/ml) and myocardial tissue (left ventricle: 143.2 ng/g, right ventricle: 159.7 ng/g).
Tissue-to-plasma ratios ranged from 0.8 to 2.1.
These levels suggest death occurred during the early distribution phase of the drug.

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Implications:

This case highlights the rapid toxicity and distribution of beta-methyldigoxin following overdose.
Accurate postmortem analysis is crucial for determining cause of death in suspected glycoside poisoning.
Understanding drug distribution kinetics aids in forensic investigations.