Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antenatal dexamethasone and subsequent lung growth

Y C Wong, C S Beardsmore, M Silverman

    Archives of Disease in Childhood
    |July 1, 1982
    PubMed
    Summary

    Antepartum dexamethasone exposure did not affect lung development in very low birthweight infants. A 12-month follow-up found no differences in lung size or mechanics between treated and control groups.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Exclusive viral wheeze and allergic wheeze: evidence for discrete phenotypes.

    The European respiratory journal·2011
    Same author

    The shifting sands of research ethics and governance: effect on research in paediatrics.

    Archives of disease in childhood·2006
    Same author

    Standardizing lung function laboratories for multicenter trials.

    Pediatric pulmonology·2006
    Same author

    Ethical issues in lung function testing in children.

    Paediatric respiratory reviews·2005
    Same author

    Are ethnic differences in lung function explained by chest size?

    Archives of disease in childhood. Fetal and neonatal edition·2005
    Same author

    Breath-hold MRI in evaluating patients with pectus excavatum.

    The British journal of radiology·2001

    Area of Science:

    • Neonatal medicine
    • Pediatric pulmonology
    • Pharmacology

    Background:

    • Very low birthweight infants (<1500g) face potential long-term health challenges.
    • Antepartum corticosteroid use is common in high-risk pregnancies.
    • The impact of prenatal dexamethasone on infant lung development requires further investigation.

    Purpose of the Study:

    • To evaluate the long-term effects of antepartum dexamethasone on lung size and mechanics in very low birthweight infants.
    • To determine if prenatal dexamethasone exposure impacts lung development during the first year of life.

    Main Methods:

    • A 12-month follow-up study was conducted on 15 very low birthweight infants.
    • Seven infants received antepartum dexamethasone (mean dose 21 mg).
    • Infants were assessed for thoracic gas volume, dynamic pulmonary compliance, and airways resistance.

    Main Results:

    • No significant differences were observed between the dexamethasone-exposed and control groups.
    • Lung function parameters including thoracic gas volume, dynamic pulmonary compliance, and airways resistance were comparable.
    • No adverse effects on lung growth and development were detected.

    Conclusions:

    • Antepartum dexamethasone exposure does not appear to adversely affect lung growth and mechanics in very low birthweight infants.
    • Prenatal dexamethasone treatment is likely safe concerning early lung development.
    • Further research may explore effects at later developmental stages.

    Related Experiment Videos