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The eosinophil and the lung

M Schatz, S Wasserman, R Patterson

    Archives of Internal Medicine
    |August 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Eosinophils play dual roles in health and disease, with some components offering benefits and others causing harm. Understanding eosinophil function is crucial for diagnosing and managing pulmonary diseases like asthma and pneumonia.

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    Area of Science:

    • Immunology
    • Pulmonology

    Background:

    • Eosinophils, a type of white blood cell, have complex roles in both beneficial immune responses and detrimental tissue damage.
    • Their constituents can modulate allergic reactions and combat parasitic infections, but also contribute to tissue destruction.

    Purpose of the Study:

    • To expand the understanding of eosinophil function in health and disease.
    • To explore the clinical significance of eosinophils in obstructive and infiltrative pulmonary diseases.

    Main Methods:

    • Review of current concepts on eosinophil morphology, constituents, distribution, and kinetics.
    • Analysis of the role of eosinophils in obstructive lung diseases, correlating peripheral eosinophil counts with obstruction severity.
    • Presentation of an updated classification for pulmonary infiltrates with eosinophilia, based on causes and syndromes.

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    Main Results:

    • Eosinophil constituents exhibit both beneficial (e.g., modulating mast cell reactions, helminthotoxicity) and detrimental (e.g., tissue destruction) effects.
    • Peripheral eosinophilia in obstructive lung disease indicates reversibility and correlates with obstruction severity.
    • An updated classification aids in diagnosing various infiltrative pulmonary diseases associated with eosinophilia.

    Conclusions:

    • Eosinophils are key players in pulmonary diseases, with their counts reflecting disease characteristics.
    • Recognizing the dual nature of eosinophils is vital for effective clinical management.
    • An updated classification framework improves the diagnosis of eosinophilic lung diseases.