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Experiences with fluorophotometry

A M Brooks

    Australian Journal of Ophthalmology
    |February 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Fluorophotometry reveals abnormal fluorescein distribution in various eye diseases, aiding diagnosis. Age and iris pigmentation influence fluorescein levels, impacting interpretation of ocular conditions.

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    Area of Science:

    • Ophthalmology
    • Medical Imaging
    • Biomedical Optics

    Background:

    • Slit-lamp fluorophotometry is a valuable tool for assessing ocular fluid dynamics.
    • Understanding fluorescein distribution is crucial for diagnosing and managing various retinal and choroidal diseases.

    Purpose of the Study:

    • To characterize normal fluorescein distribution in the anterior and posterior segments of the eye using fluorophotometry.
    • To investigate the correlation between fluorescein levels and specific ocular pathologies, age, and iris pigmentation.
    • To evaluate the diagnostic utility of fluorophotometry in differentiating ocular conditions.

    Main Methods:

    • Utilized Metricon Model 120 slit-lamp fluorophotometer for anterior and posterior ocular focus.
    • Performed fluorescein injections and recorded tracings before and after, analyzing changes over time.
    • Correlated fluorescein levels with age, iris pigmentation, and diagnosed ocular conditions.

    Main Results:

    • Identified distinct fluorescein peaks in the cornea and ciliary region, and a chorioretinal peak with a mid-vitreous minimum.
    • Observed higher fluorescein levels post-injection, increasing with age and in non-pigmented irides.
    • Detected abnormally high fluorescein levels in fellow eyes with retinal vein occlusion, diabetes, macular degeneration, retinopathy, and optic neuritis.
    • Demonstrated fluorophotometry's utility in differentiating choroidal melanoma from benign lesions.
    • Found no correlation between hemoglobin A1C and fluorescein leakage in diabetics.

    Conclusions:

    • Fluorophotometry effectively maps fluorescein distribution, revealing characteristic patterns in various ocular diseases.
    • Abnormal fluorescein leakage is a significant indicator in conditions like diabetic retinopathy and retinal vein occlusion.
    • This technique aids in differential diagnosis, particularly for choroidal melanomas, and its interpretation requires consideration of age and iris pigmentation.