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Related Experiment Videos

Left ventricular function in hypothyroidism. Responses to exercise and beta adrenoceptor blockade

J C Forfar, A L Muir, A D Toft

    British Heart Journal
    |September 1, 1982
    PubMed
    Summary

    Thyroid hormone deficiency reversibly impairs left ventricular function. However, responses to exercise and beta-blockers remain normal, indicating no altered adrenergic sensitivity in hypothyroidism.

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    Area of Science:

    • Cardiology
    • Endocrinology
    • Exercise Physiology

    Background:

    • Thyroid hormones are crucial for cardiovascular function.
    • Hypothyroidism can lead to impaired cardiac performance.
    • The impact of hypothyroidism on left ventricular function during stress and beta-blockade requires further elucidation.

    Purpose of the Study:

    • To investigate the effects of exercise and beta-blockade on left ventricular function in hypothyroid patients.
    • To assess the reversibility of cardiac dysfunction with thyroxine replacement.
    • To determine if adrenergic sensitivity is altered in hypothyroidism.

    Main Methods:

    • Eight hypothyroid patients underwent radionuclide ventriculography at rest and during exercise.
    • Left ventricular ejection fraction was measured before and during thyroxine treatment.

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  • Intravenous propranolol was administered to assess beta-adrenoceptor blockade effects.

    • Main Results:

    • Left ventricular ejection fraction was reduced at rest and during exercise in hypothyroid patients.
    • Thyroxine replacement normalized left ventricular function.
    • Exercise-induced increase in ejection fraction and response to propranolol were similar in hypothyroid and euthyroid states.

    Conclusions:

    • Left ventricular function is reversibly depressed in hypothyroidism.
    • Responses to exercise and beta-adrenergic blockade are preserved.
    • There is no evidence of altered adrenergic sensitivity in myocardial contractility control in hypothyroidism.