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Related Experiment Videos

Cutaneous polyamines in psoriasis

N J Lowe, J Breeding, D Russell

    The British Journal of Dermatology
    |July 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Polyamines like putrescine, spermidine, and spermine are altered in psoriasis. Both involved and uninvolved psoriatic skin show abnormal polyamine metabolism and increased ornithine decarboxylase activity.

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    Area of Science:

    • Biochemistry
    • Dermatology
    • Cell Biology

    Background:

    • Polyamines (putrescine, spermidine, spermine) are crucial for cell growth and division.
    • Previous research indicated altered polyamine levels and ornithine decarboxylase (ODC) activity in psoriatic skin.
    • Psoriasis is a chronic inflammatory skin condition characterized by abnormal cell proliferation.

    Purpose of the Study:

    • To investigate cutaneous polyamine levels and ODC activity in patients with psoriasis compared to normal subjects.
    • To determine if polyamine metabolism is altered in both lesional and non-lesional psoriatic skin.

    Main Methods:

    • Epidermal shave biopsies were obtained from psoriatic lesions, uninvolved psoriatic skin, and normal skin.
    • Assays were performed to measure ODC activity and levels of putrescine, spermidine, and spermine.

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    Main Results:

    • Psoriatic lesions exhibited significantly higher ODC activity than uninvolved skin.
    • Uninvolved psoriatic skin also showed higher ODC activity compared to normal skin.
    • Putrescine levels were elevated in involved psoriatic skin. Spermidine and spermine levels were increased in both involved and uninvolved psoriatic skin compared to normal skin. The spermidine/spermine ratio was highest in involved psoriatic skin.

    Conclusions:

    • These findings confirm abnormal polyamine metabolism in both involved and uninvolved skin of patients with psoriasis.
    • Altered polyamine profiles and elevated ODC activity are characteristic features of psoriatic skin, suggesting their role in the disease pathogenesis.