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Obligatory amino acids in primitive proteins

A S Kolaskar, V Ramabrahmam

    Bio Systems
    |January 1, 1982
    PubMed
    Summary

    Researchers identified six essential amino acids (Ser, Val, Leu, Asp, Gly, Pro) that conformationally represent all others in primitive proteins. These

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    Area of Science:

    • Biochemistry and Molecular Biology
    • Protein Structure and Evolution

    Background:

    • Amino acid residues exhibit conformational similarities.
    • Analysis of (phi, psi)-probability distributions reveals these similarities across 20 proteinous amino acids.
    • Understanding these conformational properties is key to deciphering early protein evolution.

    Purpose of the Study:

    • To identify a core set of 'obligatory' amino acids in primitive proteins based on conformational similarity.
    • To determine which amino acids can conformationally represent the remaining ones.
    • To provide a basis for understanding the fundamental building blocks of early protein structures.

    Main Methods:

    • Analyzed (phi, psi)-probability distributions for all 20 proteinous amino acids.
    • Utilized data from 38 different globular proteins.
    • Identified conformational similarities to define 'obligatory' amino acids.

    Main Results:

    • A set of six 'obligatory' amino acids was identified: Serine (Ser), Valine (Val), Leucine (Leu), Aspartic acid (Asp), Glycine (Gly), and Proline (Pro).
    • These six amino acids conformationally represent the properties of the other 14 amino acids.
    • The study discusses the rationale for selecting these specific residues as 'obligatory'.

    Conclusions:

    • Ser, Val, Leu, Asp, Gly, and Pro are proposed as 'obligatory' amino acids for primitive proteins due to their conformational representativeness.
    • This finding offers insights into the minimal set of amino acids required for early protein structural diversity.
    • Methods for validating this proposition are suggested, paving the way for further research.

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