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Nerve cell loss with aging in the putamen

O Bugiani, S Salvarani, F Perdelli

    European Neurology
    |January 1, 1978
    PubMed
    Summary

    Aging correlates with a decrease in nerve cells within the putamen, affecting both small and large neurons. This neuronal loss may impact the extrapyramidal system

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    Area of Science:

    • Neuroscience
    • Aging Research
    • Neuroanatomy

    Background:

    • The putamen is a key component of the basal ganglia, crucial for motor control.
    • Age-related neuronal loss is a known phenomenon in the brain, but specific impacts on the putamen require further elucidation.

    Purpose of the Study:

    • To investigate the relationship between chronological age and neuronal cell count in the human putamen.
    • To determine if neuronal loss in the putamen is selective for cell size or affects all neuronal populations proportionally.

    Main Methods:

    • Quantitative histological analysis of post-mortem putamen tissue.
    • Cell counting and size assessment in different regions of the putamen.

    Main Results:

    • A significant negative correlation was observed between age and the total number of nerve cells in the putamen.
    • Both small and large neuronal populations within the putamen showed a proportional decrease in cell number with advancing age.

    Conclusions:

    • Neuronal cell loss in the putamen is a significant feature of aging.
    • The proportional involvement of both small and large neurons suggests a global impact of aging on this brain structure.
    • This age-related neuronal attrition in the putamen may have implications for motor function and the broader extrapyramidal system.

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