Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does local tumour heating im mice influence metastatic spread?

S A Hill, J Denekamp

    The British Journal of Radiology
    |June 1, 1982
    PubMed
    Summary

    Local tumor hyperthermia combined with radiation therapy does not increase the risk of distant metastases. Studies show that neither pre- nor post-irradiation heating significantly alters metastasis incidence, suggesting safety in clinical applications.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effectiveness of slow motion video compared to real time video in improving the accuracy and consistency of subjective gait analysis in dogs.

    Open veterinary journal·2015
    Same author

    [Secretion of saliva in ingestion of kefir and milk, acidified by lactic acid; experimental study].

    Voprosy pediatrii·2014
    Same author

    Slow, reversible, coupled folding and binding of the spectrin tetramerization domain.

    Biophysical journal·2012
    Same author

    Tumour vascular disrupting agents: combating treatment resistance.

    The British journal of radiology·2008
    Same author

    Physiological and metabolic adaptations of Potamogeton pectinatus L. tubers support rapid elongation of stem tissue in the absence of oxygen.

    Plant & cell physiology·2005
    Same author

    The endothelin B (ETB) receptor agonist IRL 1620 is highly vasoconstrictive in two syngeneic rat tumour lines: potential for selective tumour blood flow modification.

    British journal of cancer·2005

    Area of Science:

    • Oncology
    • Radiation Oncology
    • Medical Physics

    Background:

    • Hyperthermia, or heat therapy, is explored as an adjunct to radiation therapy for cancer treatment.
    • The potential impact of hyperthermia on the metastatic spread of cancer requires thorough investigation.
    • Understanding the relationship between local tumor hyperthermia and metastasis is crucial for optimizing cancer treatment protocols.

    Purpose of the Study:

    • To evaluate the effect of local tumor hyperthermia, when combined with radiation therapy, on the incidence of distant metastases.
    • To determine if the timing of heat application (before or after irradiation) influences metastatic spread.
    • To assess the metastatic risk associated with fractionated hyperthermia combined with curative radiation doses.

    Main Methods:

    • Conducted retrospective analysis of data from regrowth delay experiments involving palliative radiation doses with or without heat (42.8°C/h).
    • Performed prospective studies with locally controlled primary tumors, applying heat immediately before or after irradiation.
    • Investigated the effect of whole-body heating and fractionated hyperthermia (4 heat doses plus curative radiation) on metastasis incidence.

    Main Results:

    • Retrospective analysis showed a significant increase in metastases in only one of five tumors when heated immediately before palliative radiation.
    • Prospective studies indicated no significant change in metastasis incidence when local heat was applied immediately before or after irradiation.
    • Whole-body heating showed a marginally significant increase in metastases, while fractionated hyperthermia did not significantly alter metastasis frequency.

    Conclusions:

    • Local tumor hyperthermia combined with radiation therapy does not appear to increase the risk of distant metastatic spread.
    • The timing and modality of hyperthermia application (local vs. whole-body, fractionated vs. single) may influence metastatic potential.
    • Current findings suggest that local hyperthermia can be safely integrated with radiation therapy without elevating metastatic risk.

    Related Experiment Videos