Biological properties of N4-spermidine derivatives and their potential in anticancer chemotherapy

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Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse.

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Sterol carrier protein-2: structure reveals function.

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Control of irritable bowel syndrome with polyamine analogs: a structure-activity study.

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Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype.

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Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells.

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Motif-Selective DNA Recognition and Promoter-Dependent Transcriptional Repression by a Cyclic Pyrrole/Lysine Polyamide.

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Chemistry & biodiversity·2026

Macrocyclization of ω-Isocyano Aldehydes.

Angewandte Chemie (International ed. in English)·2026

Encleistoids A-M, C-ring aromatized ent-cleistanthane diterpenoids with anti-HIV activity from two Phyllanthaceae species.

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Biological properties of N4-spermidine derivatives and their potential in anticancer chemotherapy

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Polyamine biosynthesis impacts cellular folate requirements necessary to maintain S-adenosylmethionine and nucleotide pools.

Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse.

Sterol carrier protein-2: structure reveals function.

Control of irritable bowel syndrome with polyamine analogs: a structure-activity study.

Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype.

Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells.

INSR Armoring Protects CAR-NK and CAR-T Cells Against Tumor Stroma-Induced CAR Shedding by Maintaining Cholesterol Homeostasis.

Sodium-Glucose Cotransporter SGLT2 Supports Metabolic Fitness and Ferroptosis Resistance in CAR-T Cells to Enhance Activity Against Solid Tumors.

Paired Single-Cell Profiling Reveals Glutathione-Dependent Immune Evasion in Breast Cancer Liver Metastasis.

ANXA1 Promotes Endoplasmic Reticulum-Mitochondria Calcium Coupling to Sustain Lenvatinib Resistance in Hepatocellular Carcinoma.

The HDAC8-U2AF1 Axis Dysregulates DNA Damage-Responsive RNA Splicing and Creates Targetable Vulnerabilities in Acute Myeloid Leukemia.

Single-Cell and Spatial Transcriptomics Reveal CHCHD3 as a Therapeutic Target to Activate cGAS-STING and Overcome Immunosuppression in Lung Adenocarcinoma.

Design, synthesis, and biological evaluation of pyrimidine linked fused thiazole-isoxazole conjugates as dual cholinesterase inhibitors for Alzheimer's disease.

Motif-Selective DNA Recognition and Promoter-Dependent Transcriptional Repression by a Cyclic Pyrrole/Lysine Polyamide.

Development of Benzothiophene-Bearing Bis-oxadiazole Derivatives for Potential Anticancer Targets: Evaluation of DFT, ADME-Tox, and In Silico Docking.

Macrocyclization of ω-Isocyano Aldehydes.

Encleistoids A-M, C-ring aromatized ent-cleistanthane diterpenoids with anti-HIV activity from two Phyllanthaceae species.

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