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Cardiac catheterization dye does not affect serum thyroid hormone concentrations or TSH secretion
Catheterization and Cardiovascular Diagnosis
|January 1, 1982
Summary
Iodinated contrast agents for oral cholecystography affect thyroid hormones. However, diatrizoate used in coronary angiography does not significantly alter thyroid hormone levels in euthyroid patients.
Area of Science:
- Endocrinology
- Radiology
- Pharmacology
Background:
- Iodinated contrast agents for oral cholecystography are known to impact peripheral iodothyronine-5'-deiodinase activity.
- This impact leads to transient changes in serum thyroid hormone concentrations, including decreased triiodothyronine (T3) and increased reverse T3 (rT3) and thyroxine (T4).
Purpose of the Study:
- To investigate the effect of diatrizoate, an iodinated contrast agent used in coronary angiography, on thyroid hormone metabolism.
- To assess the impact of diatrizoate on serum concentrations of thyroxine (T4), triiodothyronine (T3), reverse T3 (rT3), and thyroid stimulating hormone (TSH).
- To evaluate the TSH and T3 responses to thyrotropin releasing hormone (TRH) after diatrizoate administration.
Main Methods:
- Seven euthyroid patients undergoing coronary angiography were studied.
- Serum concentrations of T4, T3, rT3, and TSH were measured before and on the fifth day after the procedure.
- TSH and T3 responses to TRH stimulation were also assessed.
Main Results:
- No significant changes were observed in serum T4, T3, rT3, or TSH concentrations following coronary angiography with diatrizoate.
- The TSH and T3 responses to TRH remained unaffected.
Conclusions:
- Diatrizoate, unlike oral cholecystographic contrast agents, appears to have minimal to no clinically significant effect on thyroid hormone metabolism in humans.
- Coronary angiography using diatrizoate is unlikely to cause clinically important alterations in thyroid function.