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[A micro-method developed for prothrombin time assay (author's transl)]

M Takizawa, R Yajima, S Hayashi

    Jikken Dobutsu. Experimental Animals
    |July 1, 1978
    PubMed
    Summary
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    A new micro-method using PARAFILM accurately measures prothrombin time in various animal models. This cost-effective technique shows high correlation with established methods, proving useful for assessing blood coagulability.

    Area of Science:

    • Biochemistry
    • Hematology
    • Veterinary Medicine

    Background:

    • Accurate measurement of prothrombin time (PT) is crucial for assessing blood coagulability.
    • Existing methods may require significant sample volumes or specialized equipment.
    • Development of micro-methods offers potential for reduced sample requirements and increased accessibility.

    Purpose of the Study:

    • To develop and validate a novel micro-method for determining prothrombin time.
    • To evaluate the performance of this new method using readily available materials like PARAFILM.
    • To compare the results with a standard method (Quick) and establish its physiological relevance across species.

    Main Methods:

    • A new micro-method for prothrombin time measurement was developed utilizing PARAFILM.

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  • The micro-method was comparatively studied against the Quick method in rats.
  • Physiological prothrombin time values were determined for rabbits, dogs, mice, cats, rats, and guinea pigs using the new method.

    • Main Results:

    • The newly developed micro-method demonstrated a strong correlation (r=0.951) with the Quick method in rats.
    • The method yielded physiological prothrombin time values for multiple species, including rabbits (9.8 sec), dogs (12.5 sec), mice (13.3 sec), cats (14.8 sec), and rats (16.0 sec).
    • Guinea pigs exhibited the longest prothrombin time at 25.3 sec.

    Conclusions:

    • The PARAFILM-based micro-method is a reliable and useful tool for assessing blood coagulability.
    • This method offers a practical alternative for prothrombin time determination, particularly in resource-limited settings.
    • The study provides species-specific reference ranges for prothrombin time using the novel micro-assay.