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Trace elements analysis in biological samples by proton nuclear activation

M C Cantone, N Molho, L Pirola

    Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Fur Medizinische Physik and the European Federation of Organisations for Medical Physics
    |February 1, 1982
    PubMed
    Summary

    A new method using medium energy proton nuclear activation (PNA) accurately analyzes trace elements like Sr, Cu, Fe, Zn, and Se in human serum. This technique was validated and applied to study zinc levels in children.

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    Area of Science:

    • Analytical Chemistry
    • Nuclear Physics
    • Biomedical Analysis

    Background:

    • Accurate multielemental analysis of biological samples is crucial for diagnostics.
    • Existing methods may have limitations in sensitivity or sample throughput.
    • Trace elements play vital roles in human health and disease.

    Purpose of the Study:

    • To develop and validate a novel method for multielemental trace element analysis in biological samples.
    • To quantify specific trace elements (Sr, Cu, Fe, Zn, Se) in human serum.
    • To assess the clinical relevance of this method through a study on zinc levels in children.

    Main Methods:

    • Medium energy proton nuclear activation (PNA) using a 23 MeV proton beam.
    • (p, 2n) nuclear reactions were utilized for elemental activation.

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  • Quantitative analysis was performed using an internal reference method and a doped serum standard.

    • Main Results:

    • The developed PNA method demonstrated linearity, reproducibility, and reliability.
    • Quantitative concentrations of Sr, Cu, Fe, Zn, and Se were determined in human serum samples.
    • Preliminary clinical investigation on serum zinc content in children was successfully conducted.

    Conclusions:

    • Medium energy proton nuclear activation is a reliable technique for multielemental trace analysis in human serum.
    • The method provides accurate quantification of essential and non-essential trace elements.
    • This approach holds promise for clinical investigations and biological sample analysis.