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A double-blind study of cefaclor and amoxycillin in home and hospital-acquired infections
Abstract:
Eighty-seven patients admitted to hospital for a variety of reasons and who had, or subsequently developed, an infection were treated with either cefaclor or amoxycillin, 150 mg 3-times daily, on a double-blind basis. Two patients were excluded from te final analysis as the infecting organisms would normally be resistant to both antibiotics. Forty (93%) patients treated with cefaclor and 40 (95.2%) treated with amoxycillin responded satisfactorily. Of the patients with a hospital-acquired infection, 93.3% of the cefaclor group and 94.3% of the amoxycillin group responded satisfactorily. The differences between the groups were not significant. A greater number of organisms were sensitive to cefaclor, confirming its broader spectrum of activity. It is concluded that cefaclor is a useful first-line antibiotic which could be particularly useful in hospital-acquired infections.
Insights
Cefaclor and amoxicillin showed similar effectiveness in treating hospital infections. Cefaclor demonstrated a broader spectrum of activity, making it a valuable option for hospital-acquired infections.
Area of Science:
- Infectious Diseases
- Pharmacology
- Clinical Microbiology
Background:
- Hospital-acquired infections pose significant treatment challenges.
- Antibiotic resistance necessitates evaluation of broad-spectrum agents.
Purpose of the Study:
- To compare the efficacy of cefaclor and amoxicillin in treating infections.
- To assess the utility of cefaclor, particularly in hospital-acquired infections.
Main Methods:
- A double-blind study involving 87 patients with infections.
- Treatment with cefaclor or amoxicillin (150 mg, 3 times daily).
- Exclusion of patients with inherently resistant organisms.
Main Results:
- Similar satisfactory response rates for cefaclor (93%) and amoxicillin (95.2%).
- High efficacy in hospital-acquired infections for both antibiotics (93.3% cefaclor, 94.3% amoxicillin).
- Cefaclor exhibited sensitivity against a wider range of microorganisms.
Conclusions:
- Cefaclor is an effective first-line antibiotic.
- Cefaclor is particularly beneficial for treating hospital-acquired infections due to its broader spectrum.