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Intestinal ischemia and shock factors

U Haglund, O Lundgren

    Federation Proceedings
    |November 1, 1978
    PubMed
    Summary

    Reduced blood flow to the small intestine causes villous damage and cardiovascular issues. This study identified cardiotoxic substances in intestinal blood, linked to damage and affecting heart function.

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    Area of Science:

    • Gastroenterology
    • Cardiology
    • Toxicology

    Background:

    • Reduced perfusion pressure to the small intestine leads to villous damage and cardiovascular derangement.
    • Previous hypotheses suggested blood/fluid pooling in the intestine caused these effects.

    Purpose of the Study:

    • To investigate the cause of cardiovascular derangement following intestinal ischemia.
    • To identify and characterize cardiotoxic substances in intestinal venous blood.

    Main Methods:

    • Experiments on cats subjected to reduced intestinal perfusion pressure.
    • In vivo and in vitro studies using working rat hearts and isolated rabbit papillary muscles.
    • Analysis of intestinal venous blood for cardiotoxic material.

    Main Results:

    • Cardiovascular derangement was not due to intestinal blood/fluid pooling.
    • Cardiotoxic material was detected in cat intestinal venous blood.
    • A correlation exists between villous damage severity and cardiotoxic material presence.
    • The cardiotoxic material comprises heat-stable, water-soluble (500-1000 Da) and lipid-soluble fractions.

    Conclusions:

    • Cardiotoxic substances released from the damaged small intestine contribute to cardiovascular derangement.
    • These toxins, with distinct solubility and molecular properties, play a role in post-ischemic cardiovascular dysfunction.

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