[Secretory cycle of pancreatic acinar cells in different functional states]

Time parameter and secretory cycle in acinar cells of the pancreas were studied after atropine, trazilol, pilocarpine administration, and subtotal resection of the small intestine. The duration of secretory cycle was found to be about 45 min. in intact rats. Atropine and trazilol suppressed the secretion process, first inhibiting the release of the formed product and then reducing the synthesis. Pilocarpine first accelerated but very soon decreased the synthetic process. A marked acceleration of synthesis and intensification of secretory cycle in glandular cells occurred in postresectional period. Interrelationships of intracellular mechanisms for the product release and synthesis of new protein molecules, are discussed.