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Acetylator status and diabetic neuropathy

G M Shenfield, V J McCann, R Tjokresetio

    Diabetologia
    |June 1, 1982
    PubMed
    Summary

    Diabetic patients, especially Type 1, show a higher prevalence of fast acetylator status. High glucose levels may influence this finding, suggesting acetylator status as a potential, but not yet confirmed, genetic marker for diabetes.

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    Area of Science:

    • Pharmacogenetics
    • Metabolic Disorders
    • Clinical Biochemistry

    Background:

    • Acetylator status, a measure of drug metabolism, varies among populations.
    • Diabetes mellitus, particularly Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent), involves complex metabolic alterations.
    • Previous research has explored associations between acetylator status and diabetic complications, with varying results.

    Purpose of the Study:

    • To investigate the prevalence of different acetylator statuses in normal subjects and patients with Type 1 and Type 2 diabetes.
    • To examine the association between acetylator status and peripheral neuropathy in diabetic patients.
    • To explore the potential of acetylator status as a genetic marker for diabetes and its relationship with glycemic control.

    Main Methods:

    • Acetylator status was determined in 112 normal subjects and 116 diabetic patients (Type 1 and Type 2).
    • Statistical analyses were performed to compare acetylator status prevalence between groups.
    • Associations with peripheral neuropathy and plasma glucose levels were assessed.

    Main Results:

    • Fast acetylator prevalence was significantly higher in Type 1 diabetes (74%) and intermediate in Type 2 diabetes (54%) compared to normal subjects (48%).
    • No significant association was found between acetylator status and peripheral neuropathy in either diabetic group.
    • The rate of sulphadimidine acetylation was higher in diabetic patients, and high plasma glucose showed a significant association with acetylator status.

    Conclusions:

    • Acetylator status differs significantly between normal individuals and Type 1 diabetic patients.
    • High glucose levels might contribute to the observed acetylator status distribution, suggesting a potential artefact rather than a solely genetic link.
    • Further prospective studies are required to validate acetylator status as a genetic marker for diabetes.

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