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Amphetamine abuse and transsexualism

The Journal of Nervous and Mental Disease

|September 1, 1982

Summary

This case study explores a unique instance of temporary transsexual episodes linked to methamphetamine abuse in a male patient. Findings suggest a potential neurochemical basis for these drug-induced gender identity experiences.

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Area of Science:

Neuroscience
Psychiatry
Addiction Medicine

Background:

Investigating the complex interplay between substance abuse and gender identity.
Understanding the neurobiological underpinnings of transient gender dysphoria.

Observation:

A male patient experienced self-labeled transsexual episodes exclusively following intravenous methamphetamine use.
The patient identified as masculine and lacked cross-gender desires outside of stimulant intoxication.

Findings:

The study presents a rare case linking amphetamine abuse to temporary, drug-induced transsexualism.
This phenomenon suggests a potential neurochemical mechanism influencing gender identity expression.

Implications:

Highlights the need to consider substance abuse in the differential diagnosis of gender identity presentations.
Opens avenues for research into drug-induced alterations of neurochemistry and their effect on identity.

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