The role of gastric secretion in post-diverted pancreatic hypersecretion in conscious rats

1. In rats prepared with chronic external pancreatic fistulae, gastric fistulae and choledocho-enterostomy, the volume and protein secretion of pancreatic juice was measured. 2. The pancreatic secretion of water and protein after juice diversion was significantly lower when the gastric fistula was open than when closed. Secretion was abolished after atropine, with the fistula open and in animals with ligated pylori. 3. Intraduodenal HCl significantly raised juice volume and protein in animals with diverted juice when the gastric fistula was open. 4. Soybean trypsin inhibitor produced a significantly smaller elevation of juice volume and protein when the gastric fistula was open. 5. It is concluded that the initial hypersecretion of pancreatic juice and protein, following its diversion from the duodenum, is a consequence of the entry of gastric juice into the intestine.