Differentiation of amphetamine and its major hallucinogenic derivatives using thin-layer chromatography

Psychotropic, ring-substituted amphetamine derivatives can be differentiated from each other and from over-the-counter drugs using a sequential TLC detection technique. The improved detection is accomplished by distinct differences in color through four detection stages. Reported in the tables are Rf values in two solvent systems, the color characteristics through the four detection stages and in two confirmatory reagents, and the minimum detectible concentrations in urine of 19 amphetamine derivatives.