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Localized large cell lymphoma cured by simple excision

H J Ree, J P Crowley, T S Micolonghi

    Journal of Surgical Oncology
    |September 1, 1982
    PubMed
    Summary
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    A rare case of localized diffuse large cell lymphoma (DLCL) achieved 20-year disease-free survival after simple excision. This suggests localized DLCL with specific histological features may have a favorable prognosis, challenging the need for aggressive treatment.

    Area of Science:

    • Oncology
    • Pathology
    • Surgical Oncology

    Background:

    • Diffuse large cell lymphoma (DLCL) is typically aggressive, often requiring intensive treatment.
    • Localized DLCL presentation necessitates evaluation of treatment strategies.
    • The natural history of DLCL often involves rapid progression.

    Observation:

    • A patient with localized DLCL in the right cervical region underwent simple excision.
    • The patient remained disease-free for 20 years post-excision.
    • Biopsy revealed characteristic histological features, including orderly tumor cell growth and sclerosis.

    Findings:

    • Minimal therapy (simple excision) led to long-term remission in a localized DLCL case.
    • Specific histological features, such as orderly growth and sclerosis, were noted.

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  • The patient's outcome challenges the standard aggressive treatment paradigm for localized DLCL.

    • Implications:

    • Localized DLCL with favorable histological features may not require aggressive multimodal therapy.
    • Identifying these specific morphologic features could guide treatment decisions for DLCL.
    • This case highlights the potential for favorable prognoses in select DLCL patients with localized disease.