Chromosomal aberrations induced by ethylene oxide in a human amniotic cell line in vitro

Ethylene oxide was found to be a potent inducer of chromatid-type aberrations in a human amniotic cell line. This induction was dose-dependent. At doses corresponding to about 9% survival, the number of chromatid exchanges was increased about 20 times, and the number of induced breaks increased 50 times, above that observed in the controls.