Serum alpha-1-acid glycoprotein (orosomucoid) in uremic patients on hemodialysis

The alpha 1-acid glycoprotein (orosomucoid) concentration in the serum of 34 uremic patients on chronic hemodialysis was measured twice at intervals of 3 months. In 80% of the cases the concentrations are above normal. Furthermore, the examination showed a correlation between the concentrations at the first and at the second measurement. No change in se-orosomucoid concentration was observed during hemodialysis. We therefore conclude that orosomucoid cannot be used as an acute phase reactant among uremic patients in chronic hemodialysis neither is it very likely that the hyperlipidemia and accelerated atherosclerosis in hemodialysis patients are due to lack of orosomucoid.