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Eosinophilic nonallergic rhinitis in children

G H Rupp, R A Friedman

    Pediatrics
    |September 1, 1982
    PubMed
    Summary

    Eosinophilic nonallergic rhinitis, characterized by nasal eosinophilia and negative allergy tests, affects children with perennial rhinitis. Steroid treatment significantly improved symptoms in these patients.

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    Area of Science:

    • Pediatrics
    • Allergy and Immunology
    • Otolaryngology

    Background:

    • Eosinophilic nonallergic rhinitis (ENAR) is a recently identified condition in adults with perennial rhinitis.
    • Key features include nasal eosinophilia, negative allergy skin tests, and normal serum IgE.
    • This study investigates ENAR in pediatric patients.

    Purpose of the Study:

    • To identify and characterize eosinophilic nonallergic rhinitis in children.
    • To evaluate treatment responses in pediatric patients with ENAR.

    Main Methods:

    • Study included 12 children (aged 6-17) with severe perennial rhinitis and nasal eosinophilia.
    • Patients underwent allergy skin testing and serum IgE measurement.
    • Treatment involved antihistamine-decongestants initially, followed by topical or systemic steroids for non-responders.

    Main Results:

    • All 12 children had nasal eosinophilia and normal serum IgE.
    • Antihistamine-decongestants provided partial relief in 7/12 patients.
    • Topical or systemic steroids resulted in dramatic symptom improvement in the remaining 5 patients.

    Conclusions:

    • Eosinophilic nonallergic rhinitis is a significant cause of perennial rhinitis in children.
    • Distinguishing ENAR from allergic rhinitis (negative tests) and vasomotor rhinitis (nasal eosinophilia, steroid response) is crucial.
    • Increased awareness of ENAR can lead to more effective therapeutic strategies in pediatric populations.

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