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Related Experiment Videos

Bioavailability of methotrexate tablets

J H Schornagel, M E Van Engelen, D De Vos

    Pharmaceutisch Weekblad. Scientific Edition
    |June 25, 1982
    PubMed
    Summary

    The bioavailability of methotrexate 10 mg tablets is 62%, with peak plasma levels reached in 1.7 hours. This study confirms the 10 mg methotrexate tablet is a suitable clinical preparation.

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    Area of Science:

    • Pharmacokinetics
    • Clinical Pharmacy
    • Drug Formulation

    Background:

    • Methotrexate is a critical chemotherapy agent.
    • Understanding oral methotrexate bioavailability is essential for effective dosing.
    • Previous studies may not fully characterize the 10 mg tablet formulation.

    Purpose of the Study:

    • To determine the bioavailability of methotrexate 10 mg tablets.
    • To characterize the pharmacokinetic profile of oral methotrexate.
    • To assess the suitability of the 10 mg tablet for clinical use.

    Main Methods:

    • Administered methotrexate 10 mg tablets to subjects.
    • Measured plasma concentrations over time.
    • Calculated key pharmacokinetic parameters including bioavailability, Cmax, Tmax, and half-life.

    Main Results:

    • The mean bioavailability of methotrexate 10 mg tablets was 62% +/- 16%.
    • Maximum plasma concentration (Cmax) of approximately 20.10(-7) mole/L was achieved around 1.7 hours post-dose.
    • The average plasma half-life of methotrexate was 2.4 hours.

    Conclusions:

    • The 10 mg methotrexate tablet formulation demonstrates acceptable bioavailability.
    • The pharmacokinetic profile supports its use in clinical settings.
    • This formulation is deemed suitable for therapeutic administration of methotrexate.

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