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[Fluorocarbons: applications to cardiovascular surgery (author's transl)]
La Nouvelle Presse Medicale
|June 26, 1982
Summary
Perfluorochemicals are synthetic compounds that carry oxygen. While effective in cardiology for blood substitution and reducing heart attack size, further research into their long-term cellular effects is required for clinical use.
Area of Science:
- Synthetic chemistry
- Biomedical engineering
- Cardiology
Context:
- Perfluorochemicals are synthetic compounds known for their high gas solubility.
- Stable oxygen-carrying emulsions are now available, enabling tissue oxygen delivery.
- Existing research shows fluorocarbons' efficacy in various cardiovascular applications.
Purpose:
- To explore the potential clinical applications of perfluorochemicals in medicine.
- To review the experimental evidence for fluorocarbons in cardiology.
- To identify the need for further research on long-term cellular effects.
Summary:
- Fluorocarbons are synthetic compounds with significant gas dissolution capabilities, including oxygen (O2).
- Oxygen-carrying perfluorochemical emulsions can deliver substantial gas volumes to perfused tissues.
- Experimental studies demonstrate fluorocarbon effectiveness in cardiopulmonary bypass, as blood substitutes, in cardioplegic and reperfusion solutions, and for reducing myocardial infarct size.
Impact:
- Perfluorochemicals show promise for extending clinical applications, particularly in cardiovascular medicine.
- Further investigation into the long-term effects of perfluorochemicals on cellular health is crucial.
- Understanding long-term cellular impacts is necessary before routine clinical adoption can be considered.