A study of the shaking and grooming induced by RX 336-M in rats

Several endogenous peptides and experimental agents induce "wet-dog" shakes and excessive grooming after acute administration to rats, but quantitative information on a possible relationship between the two behaviors is lacking. RX 336-M (7,8-dihydro-5'-6'-dimethylcyclohex-5'-eno-1',8',14 codeinone) is a novel compound which elicits dose-related shaking and grooming in the rat. We have measured and compared the shaking and grooming induced by several doses of RX 336-M (1.5-12 mg/kg, IP) in male Sprague Dawley rats at various stages of maturation. Analysis of the correlation between the number of "wet-dog" shakes and the frequency of grooming episodes indicates that a relationship may exist between the shaking and grooming. The excessive grooming induced by RX 336-M may be a mechanism by which the rat's state of arousal (raised by the shaking) is lowered and homeostasis is maintained.