Related Experiment Videos
Poly(A):poly(U); poly(O8A):poly(U); poly(A):poly(MeNH5U) and poly(O8A):poly(MeNH5U) versus Bida Semliki forest virus
Toxicology Letters
|June 1, 1982
Abstract:
Poly(A):poly(U) (polyadenylic acid:polyuridylic acid hybrid); poly(O8A):poly(U) (poly-8-oxy-adenylic acid:polyuridylic acid hybrid); poly(A):poly(MeNH5U) (polyadenylic acid-5-methylamino uridylic acid hybrid) and poly(O8A):poly(MeNH5U) (poly-8-oxyadenylic acid:poly-5-methylamino uridylic acid hybrid) were studied in chick embryos to compare the protection offered against Semliki forest virus (the Nigerian strain) AN 49809. The modified polymers showed a higher activity index but were more toxic than the unmodified analogue.