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Papillary carcinoma of choroid plexus. Light and electron microscopic study
Virchows Archiv. A, Pathological Anatomy and Histology
|January 1, 1982
Summary
This study examined two pediatric papillary carcinoma cases, revealing tumors originating in the lateral ventricle and spreading via cerebrospinal fluid. Histological and electron microscopy showed distinct cellular atypism and structural differences from choroid plexus papilloma.
Area of Science:
- Neuro-oncology
- Pediatric Pathology
- Electron Microscopy
Background:
- Papillary carcinoma is a rare brain tumor.
- Understanding its histological and ultrastructural features is crucial for diagnosis and prognosis.
Observation:
- Two pediatric cases of papillary carcinoma originating in the lateral ventricle trigone were analyzed.
- Tumors exhibited rapid spread via cerebrospinal fluid.
- Histology revealed differentiated papillary architecture resembling choroid plexus papilloma, with areas of cellular atypism and multilayering.
Findings:
- Distinct differences in PAS, Alcian blue, and orcein staining were noted compared to choroid plexus papilloma.
- Electron microscopy showed loss of apical-basal polarity and indistinct microvilli and desmosome-like structures in carcinoma cells.
Implications:
- These findings contribute to differentiating papillary carcinoma from similar brain tumors in children.
- Further research into the unique ultrastructural characteristics may improve diagnostic accuracy.
- Understanding tumor spread mechanisms is vital for developing targeted therapies.