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[Sympathico-adrenal system in lung cancer]

N A Filatova, V S Sheveleva, R I Vagner

    Voprosy Onkologii
    |January 1, 1982
    PubMed
    Summary

    Pulmonary cancer patients exhibit a weakened sympatho-adrenal system, even in early stages. Stimulating treatments can restore its normal function, offering a potential therapeutic avenue for lung cancer.

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    Area of Science:

    • Pulmonary Medicine
    • Oncology
    • Neuroendocrinology

    Background:

    • The sympatho-adrenal system (SAS) plays a crucial role in physiological responses.
    • Alterations in SAS function are implicated in various diseases, including cancer.

    Purpose of the Study:

    • To compare the functional state of the SAS in pulmonary cancer patients versus healthy individuals and those with pneumonia or tuberculosis.
    • To investigate potential interventions for normalizing SAS function in lung cancer.

    Main Methods:

    • Comparative analysis of SAS activity.
    • Assessment of SAS in patients with lung cancer, pneumonia, tuberculosis, and healthy controls.
    • Evaluation of the effects of substances stimulating redox processes and vegetative centers.

    Main Results:

    • Pulmonary cancer patients demonstrated a significantly lower tone of the sympatho-adrenal system compared to controls.
    • This hypo-function of the SAS was detectable even at the early stages of lung malignancy.
    • Administration of specific stimulating agents normalized the SAS functional state in cancer patients.

    Conclusions:

    • Reduced sympatho-adrenal system tone is a characteristic feature of pulmonary cancer, present early in the disease.
    • Interventions targeting redox processes and vegetative centers show promise in restoring SAS function in lung cancer patients.

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