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A comparative longitudinal study on sex hormone binding globulin capacity during estrogen replacement therapy
Acta Obstetricia Et Gynecologica Scandinavica
|January 1, 1982
Summary
Different estrogens impact sex hormone-binding globulin (SHBG) levels differently in postmenopausal women. Ethinyl-estradiol significantly increased SHBG, suggesting potential estrogen overtreatment.
Area of Science:
- Endocrinology
- Pharmacology
- Biochemistry
Background:
- Estrogen replacement therapy (ERT) is used in postmenopausal women.
- Sex hormone-binding globulin (SHBG) is a key protein in hormone regulation.
- Understanding ERT's effects on SHBG is crucial for safe and effective treatment.
Purpose of the Study:
- To compare the effects of different estrogens on SHBG-binding capacity.
- To determine if SHBG induction indicates estrogen overtreatment.
Main Methods:
- An aqueous two-phase equilibrium partition system was employed to measure SHBG-binding capacity.
- Serum samples from postmenopausal women were analyzed before and during ERT.
Main Results:
- Ethinyl-estradiol (0.05 mg/day) caused a 70% increase in serum SHBG.
- Estradiol-17 beta and estrone sulfate induced moderate changes in SHBG.
- Estriol did not significantly affect SHBG levels at various doses.
Conclusions:
- The induction of SHBG varies significantly among different estrogen compounds.
- High SHBG induction, particularly with ethinyl-estradiol, may signal estrogen overtreatment.
- Monitoring SHBG could be a valuable indicator in managing ERT.