Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malignant hyperthermia

M Ohmori, S Kobayashi, Y Ohtsuki

    Acta Pathologica Japonica
    |July 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Malignant hyperthermia, a rare condition, caused a patient's death following surgery. This case highlights the potential synergistic effects of hypothalamic hemorrhage and pre-existing myopathy in triggering this severe reaction.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Hormone therapy using tamoxifen in unresectable carcinoma of the pancreas--preliminary study].

    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica·1992
    Same author

    Histological pancreatitis in end-stage renal disease.

    International journal of pancreatology : official journal of the International Association of Pancreatology·1992
    Same author

    Bioavailability study of commercial sustained-release preparations of diclofenac sodium in gastrointestinal physiology regulated-dogs.

    Chemical & pharmaceutical bulletin·1992
    Same author

    Alternatively-spliced p53 mRNA in the FAA-HTC1 rat hepatoma cell line without the splice site mutations.

    Cell structure and function·1992
    Same author

    A three-dimensional observation of acid phosphatase-positive structures in rat testis by high voltage electron microscopy.

    Okajimas folia anatomica Japonica·1992
    Same author

    Retroviral-mediated gene transfer to neonatal rat hepatocytes and intrasplenic transplantation of the transduced hepatocytes.

    Transplantation proceedings·1992
    Same journal

    One step procedure of PCR-DNA extraction from paraffin-embedded materials by Chelex-100.

    Acta pathologica japonica·1993
    Same journal

    Primary hepatic carcinoid tumor.

    Acta pathologica japonica·1993
    Same journal

    Hepatocellular carcinoma with unusual metastasis to the small intestine.

    Acta pathologica japonica·1993
    Same journal

    Polymorphous low-grade adenocarcinoma of submandibular gland origin.

    Acta pathologica japonica·1993
    Same journal

    Two cases of recurrent hepatic injury associated with early pregnancy: hCG on hepatocytes is a suspected target antigen for lymphocyte attack.

    Acta pathologica japonica·1993
    Same journal

    Distribution of laminin, type IV collagen and fibronectin in the invasive component of breast carcinoma.

    Acta pathologica japonica·1993
    See all related articles

    Area of Science:

    • Neurology
    • Pathology
    • Anesthesiology

    Background:

    • Malignant hyperthermia (MH) is a severe, unpredictable pharmacogenetic disorder of skeletal muscle.
    • It is primarily associated with volatile anesthetics and succinylcholine.
    • The underlying pathophysiology involves a hypermetabolic state in skeletal muscle.

    Observation:

    • A 65-year-old male developed malignant hyperthermia (42°C) postoperatively after an anterior communicating artery aneurysm clipping.
    • Clinical presentation included significant muscle rigidity.
    • Autopsy revealed latent myopathy and a hypothalamic hemorrhage near the temperature regulation center.

    Findings:

    • Elevated serum creatine phosphokinase (CPK) at 250 U with 3.4% CPK isoenzyme 1.
    • Markedly high serum myoglobin levels (204,850 ng/ml).

    Related Experiment Videos

  • Evidence of myoglobinuric nephrosis, indicating kidney damage from myoglobin.

    • Implications:

    • This case suggests a potential synergistic interaction between hypothalamic hemorrhage and pre-existing myopathy in precipitating malignant hyperthermia.
    • Highlights the importance of considering underlying myopathies in patients experiencing unexplained hyperthermia during or after anesthesia.
    • Underscores the critical role of temperature monitoring and prompt management of hypermetabolic crises in surgical patients.