Collagen in 155 human bladders

The percentage of bladder collagen, as obtained by the dosage of hydroxyproline, was determined in autopsy specimens from 48 female and 107 male cadavers. The average percentage of collagen in the human bladder is 57.4 per cent (+/- 9) of the dry weight of insoluble protein. There is good correlation (r = 0.55) between detrusor and trigone collagen content. There is no significant difference between pre- and postpuberty age groups in relative collagen content. In females more than 50 years of age there is a significant increase in collagen.