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Related Experiment Videos

Sympathetic nerve discharge in chronic spinal cat

J L Ardell, S M Barman, G L Gebber

    The American Journal of Physiology
    |September 1, 1982
    PubMed
    Summary

    Chronic spinal cats lack the ability to generate slow-wave sympathetic nerve discharge (SND) rhythm. Coordination of sympathetic nerves requires intact bulbospinal connections, and no baroreceptor reflex controlling SND was found.

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    Area of Science:

    • Neuroscience
    • Physiology
    • Autonomic Nervous System Research

    Background:

    • Sympathetic nerve discharge (SND) is crucial for cardiovascular regulation.
    • Understanding the central control of SND is vital for treating autonomic dysfunction.
    • Previous studies in intact or baroreceptor-denervated animals have explored SND rhythm generation.

    Purpose of the Study:

    • To investigate sympathetic nerve discharge (SND) patterns in chronic spinal cats.
    • To determine the role of bulbospinal pathways in SND rhythm generation and coordination.
    • To assess the presence of baroreceptor-like reflex control of SND in chronic spinal preparations.

    Main Methods:

    • External carotid, renal, and splanchnic sympathetic nerve discharge (SND) were recorded in chloralose-anesthetized cats.
    • Cats were subjected to cervical spinal cord transection 2-37 days prior.
    • Experiments involved normocapnia, moderate hypercapnia, and ganglionic blockade.

    Main Results:

    • Minimal SND was observed 2 days post-transection; ganglionic blockade had no effect on blood pressure.
    • Hypercapnia induced slow-wave (1-6 Hz) SND, which persisted under normocapnia by 9-37 days post-transection.
    • Chronic spinal cats could not generate the 1-6 Hz rhythm, unlike baroreceptor-denervated cats.
    • Segmental sympathetic nerves showed correlated discharge, but intersegmental coordination was absent.
    • No evidence for a baroreceptor-like reflex controlling SND was found.

    Conclusions:

    • Chronic spinal cats are incapable of generating the 1-6 Hz slow-wave rhythm characteristic of SND.
    • Coordination of sympathetic nerve activity across different spinal segments necessitates intact bulbospinal connections.
    • The findings suggest that descending pathways from the brainstem are essential for generating and coordinating sympathetic outflow, and a baroreceptor reflex does not control SND in this model.

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