Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pupil cycle time in noncompressive optic neuropathy

R S Manor, Y Yassur, I Ben-Sira

    Annals of Ophthalmology
    |June 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Topical and systemic Ofloxacin (Tarivid) in the treatment of Gentamycin-resistant Pseudomonas corneal abscess.

    Ocular immunology and inflammation·2012
    Same author

    Two-point fluorophotometer for the human ocular fundus.

    Applied optics·2010
    Same author

    Spontaneous regression of optic gliomas: thirteen cases documented by serial neuroimaging.

    Archives of ophthalmology (Chicago, Ill. : 1960)·2001
    Same author

    [Photodynamic therapy in age-related macular degeneration].

    Harefuah·2000
    Same author

    [Passive smoking and its influence on the eye].

    Harefuah·2000
    Same author

    [Lowering intraocular pressure in glaucoma--by how much?].

    Harefuah·2000

    Pupil cycle time can indicate optic nerve issues, even in early multiple sclerosis. Prolonged pupil cycle time detected subclinical multiple sclerosis, confirmed by visual evoked potential analysis.

    Area of Science:

    • Ophthalmology
    • Neurology
    • Neuroscience

    Background:

    • Noncompressive optic nerve pathology presents diagnostic challenges.
    • Early detection of multiple sclerosis (MS) is crucial for timely intervention.
    • Pupil cycle time (PCT) is a physiological measure that may reflect optic nerve function.

    Purpose of the Study:

    • To investigate the correlation between pupil cycle time and clinical findings in patients with noncompressive optic nerve pathology.
    • To assess the utility of PCT in detecting subclinical multiple sclerosis.
    • To compare PCT changes with clinical disease progression in MS patients.

    Main Methods:

    • Pupil cycle time measurements were performed in 24 patients with noncompressive optic nerve pathology.
    • Visual evoked potential (VEP) analysis was used for confirmation of subclinical findings.

    Related Experiment Videos

  • Clinical assessments and follow-up evaluations were conducted.

    • Main Results:

    • A significant correlation was observed between pupil cycle time and clinical findings in the studied cohort.
    • Prolonged pupil cycle time was indicative of subclinical multiple sclerosis.
    • VEP analysis confirmed the presence of subclinical MS in cases identified by PCT.
    • Longitudinal follow-up demonstrated a correspondence between changes in clinical status and pupil cycle time in two MS patients.

    Conclusions:

    • Pupil cycle time serves as a valuable, non-invasive biomarker for noncompressive optic nerve pathology.
    • PCT can aid in the early detection of subclinical multiple sclerosis.
    • Monitoring pupil cycle time may offer insights into disease activity and progression in MS.