Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Slowly progressive aphasia without generalized dementia

M M Mesulam

    Annals of Neurology
    |June 1, 1982
    PubMed
    Summary

    This study describes a rare progressive aphasia syndrome affecting the left perisylvian region. The condition causes gradual language decline without significant early cognitive or behavioral changes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Functional Connectivity is Reduced in Early-stage Primary Progressive Aphasia When Atrophy is not Prominent.

    Alzheimer disease and associated disorders·2017
    Same author

    Linking human brain local activity fluctuations to structural and functional network architectures.

    NeuroImage·2013
    Same author

    Classification of primary progressive aphasia and its variants.

    Neurology·2011
    Same author

    Cholinergic systems in mammalian brain identified with antibodies against choline acetyltransferase.

    Neurochemistry international·2010
    Same author

    Clinical trajectories and biological features of primary progressive aphasia (PPA).

    Current Alzheimer research·2009
    Same author

    Differential sensitivity between blue and brown reaction procedures for HRP neurohistochemistry.

    Neuroscience letters·2009

    Area of Science:

    • Neuroscience
    • Neurology

    Background:

    • Investigating slowly progressing aphasic disorders.
    • Differentiating from dementia with behavioral disturbances.

    Observation:

    • Six patients presented with progressive aphasia, starting in late adulthood.
    • Initial symptoms included anomic aphasia or pure word deafness.
    • Language deficits worsened over 5-11 years, affecting reading, writing, and comprehension.

    Findings:

    • Neuroimaging showed preferential left perisylvian region involvement.
    • Cortical biopsy revealed no typical neurodegenerative markers.
    • Suggests a focal cerebral degeneration syndrome.

    Implications:

    • Highlights a distinct syndrome of focal brain degeneration.
    • May require specialized diagnostic approaches.
    • Further research into the underlying mechanisms is warranted.

    Related Experiment Videos