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[Antibiotic resistance of enterobacteria isolated from chronic bronchitis and pneumonia patients]
Abstract:
Resistance of 1060 Enterobacteria strains isolated from patients with chronic pneumonia and bronchitis was studied with respect to 15--18 antibiotics. The methods of agar dilution and sensitivity discs (Pr. mirabilis) were used. High resistance of the isolates to the antibiotics except aminoglycosides was shown. The rate, spectrum and level of the resistance were variable and changed depending on the bacterial species and drug type. The majority (77.7--100 per cent) was multiple resistant (to at least 6--10 antibiotics). The Enterobacteria populations of the respiratory origin were heterogeneous with respect to the resistance warts (61.5--85.7 per cent). The changes included elimination of the primary warts, appearance of new secondary warts or complete replacement of the variant composition. Rational therapy requires investigation of both the species and the variant composition of the microbiocenoses of the bronchial contents and their changes during the patient treatment in the hospital.
Insights
Enterobacteria in chronic respiratory infections show high antibiotic resistance, often to multiple drugs. Understanding bacterial populations is crucial for effective treatment strategies.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Context:
- Focuses on Enterobacteria strains isolated from patients suffering from chronic pneumonia and bronchitis.
- Investigates antibiotic resistance patterns in a significant sample size of 1060 strains.
Purpose:
- To determine the resistance of Enterobacteria to a panel of 15-18 antibiotics.
- To analyze the variability in resistance rates, spectrum, and levels across different bacterial species and antibiotic types.
- To assess the prevalence of multidrug resistance within these clinical isolates.
Summary:
- High levels of antibiotic resistance were observed in Enterobacteria, with most strains exhibiting multiple drug resistance (to 6-10 antibiotics).
- Aminoglycosides were generally effective, while resistance to other antibiotics was significant and varied by species and drug.
- Enterobacteria populations displayed heterogeneity in resistance characteristics, with dynamic changes in variant composition noted during patient treatment.
Impact:
- Highlights the urgent need for rational antibiotic therapy in chronic respiratory infections.
- Emphasizes the importance of investigating both species and variant composition of bronchial microbiocenoses for effective patient management.
- Provides critical data for antimicrobial stewardship and the development of targeted treatment strategies against resistant Enterobacteria.