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Related Experiment Videos

Long-term venous access in rhesus monkeys

P D Hoeprich, B M Wolfe, C Jerome

    Antimicrobial Agents and Chemotherapy
    |June 1, 1982
    PubMed
    Summary

    A new silastic reservoir catheter device enables safe, long-term intravenous infusions of medications like amphotericin B, preventing peripheral vein thrombophlebitis. This implanted system offers a feasible and well-tolerated method for central venous access.

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    Area of Science:

    • Vascular Surgery
    • Pharmacology
    • Medical Devices

    Background:

    • Peripheral vein thrombophlebitis is a risk with long-term intravenous infusions of certain medications.
    • Central venous access is often required for such treatments.
    • Existing methods may have limitations for intermittent, long-term administration.

    Purpose of the Study:

    • To evaluate the feasibility and safety of a subcutaneously implanted silastic reservoir catheter for long-term, intermittent intravenous infusions.
    • To assess the device's durability and patient tolerance.

    Main Methods:

    • Utilized a subcutaneously implanted silastic reservoir catheter for central venous access.
    • Administered medications, including amphotericin B, via percutaneous needle entry into the reservoir.
    • Employed an infusion pump for controlled substance delivery.
    • Implemented precautions against infection, clotting, and precipitate formation.

    Main Results:

    • The implanted reservoir catheter device proved feasible for long-term, intermittent intravenous infusions.
    • The device withstood at least 100 percutaneous entries with a 27-gauge needle.
    • The method was well-tolerated by patients when infection and clotting were prevented.

    Conclusions:

    • Subcutaneously implanted silastic reservoir catheters are a viable option for long-term central venous access.
    • This device facilitates safe administration of medications with a high risk of peripheral vein thrombophlebitis.
    • The system demonstrates durability and good patient tolerance with appropriate preventative measures.

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